发明名称 |
Enhancement of Pathogen-Specific Memory Th17 Cell Responses |
摘要 |
Compositions and methods for enhancing Th1/Th17 cell responses and decreasing Th2 cell responses are disclosed herein. In various embodiments the present invention describes activation of human dendritic cells and enhancement of antigen-specific T cell responses in a Dectin-1-expressing human dendritic cells comprising an anti-Dectin-1-specific antibody or fragment thereof fused with one or more antigens. TLR2 ligands may also be included to enhance the activation and for enhancement of T-cell responses. Further, the invention also includes methods based on the compositions described herein for the treatment of pathogenic infections. |
申请公布号 |
US2012128710(A1) |
申请公布日期 |
2012.05.24 |
申请号 |
US201113282112 |
申请日期 |
2011.10.26 |
申请人 |
OH SANGKON;BANCHEREAU JACQUES F.;ZURAWSKI GERARD;UENO HIDEKI;NI LING;BAYLOR RESEARCH INSTITUTE |
发明人 |
OH SANGKON;BANCHEREAU JACQUES F.;ZURAWSKI GERARD;UENO HIDEKI;NI LING |
分类号 |
A61K39/395;A61P31/16;C07K19/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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