Tricyclic antibiotics

摘要

Compound of formula (I): wherein A1 represents -O-, -S- or -N-R3; A2 represents -CH-, -O-, -N-R4, -C(=O)- or -CH(O-R4)-; A3 represents C-Ccycloalkylene; saturated and unsaturated 4 to 8-membered heterocyclodiyl with 1, 2 or 3 heteroatoms selected from nitrogen, oxygen and sulphur, which group A3 is unsubstituted or substituted; A4 represents C-Calkylene, C-Calkenylene, >C=O or a group selected from - CHNH-, -CHO-, and -CHS- being linked to the adjacent NR5-group via the carbon atom; and G represents aryl or heteroaryl, which is unsubstituted or substituted and R1 and R2 independently of one another, represent hydrogen or a substituent selected from hydroxy, halogen, mercapto, cyano, nitro, C-Calkyl, C-Calkoxy, C-Calkylthio, C-Calkylcarbonyloxy, C-Calkylsulfonyloxy, C-Cheteroalkylcarbonyloxy, C5-Cheterocyclylcarbonyloxy, C-Cheteroalkoxy, wherein heteroalkyl, heteroalkoxy groups or heterocyclyl comprise 1, 2 or 3 heteroatoms selected from nitrogen, oxygen and sulphur, in which substituents the alkyl moieties are unsubstituted or further substituted; R3, R4 and R5 independently of one another, represent hydrogen or C-Calkyl; X1 and X2 independently of one another, represent a nitrogen atom or CR2, with the proviso that at least one of Xl and X2 represents a nitrogen atom; m is 1; and the (CH2)m moiety is optionally substituted by C-Calkyl; halogen, carboxy, hydroxy, C-Calkoxy, C-C-alkylcarbonyloxy, amino, mono- or di-(C-Calkyl)amino or acylamino n is 0, 1 or 2 or pharmaceutically acceptable salt thereof are valuable for use as a medicament for the treatment of bacterial infections.