发明名称 |
MOTILIN-LIKE PEPTIDE COMPOUND HAVING TRANSMUCOSAL ABSORBABILITY IMPARTED THERETO |
摘要 |
The present invention aims at providing motilin-like peptide compounds that maintain the gastrointestinal motility stimulating activity of native motilin and which are adapted to have higher absorbability upon transmucosal administration. Motilin derivatives were designed and synthesized in consideration of the pathway for the degradation of motilin at a site of its transmucosal absorption and the maintenance of motilin's physiological activity and compounds characterized by substitutions for the amino acid at position 21 of native motilin have been found to show higher absorbability upon transmucosal administration and yet maintain the same activity as motilin.
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申请公布号 |
US2012129762(A1) |
申请公布日期 |
2012.05.24 |
申请号 |
US201013388021 |
申请日期 |
2010.07.29 |
申请人 |
SATO SEIJI;HANADA TAKESHI;WAKABAYASHI NAOMI;MASUDA YUTAKA;HARADA YURIKO;DAIICHI SANKYO COMPANY, LIMITED |
发明人 |
SATO SEIJI;HANADA TAKESHI;WAKABAYASHI NAOMI;MASUDA YUTAKA;HARADA YURIKO |
分类号 |
A61K38/16;A61P1/00;A61P1/04;A61P31/04;C07K14/00 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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