发明名称 |
Method for preparing a site-specific physiologically active polypeptide conjugate |
摘要 |
The present invention provides a method for preparing a site-specific physiologically active polypeptide conjugate in a high yield by treating a physiologically active polypeptide with a non-peptidyl polymer in the presence of an alcohol at a specific pH, which can be desirably employed in the development of long acting formulations of various peptide drugs having high in-vivo activity and markedly prolonged in-blood half-life. |
申请公布号 |
AU2010225523(B2) |
申请公布日期 |
2012.05.24 |
申请号 |
AU20100225523 |
申请日期 |
2010.03.18 |
申请人 |
HANMI HOLDINGS CO., LTD. |
发明人 |
SONG, DAE HAE;SHIN, JAE HEE;LEE, JAE MIN;PARK, YOUNG KYUNG;KWON, SE CHANG;LEE, GWAN SUN |
分类号 |
C07K1/14;C07K1/10;C07K1/18 |
主分类号 |
C07K1/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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