| 摘要 |
This invention may be used in human and veterinary medicine for the creation of a drug that is effective in the treatment of oncological illnesses in animals and humans. Summary of the Invention Modified antisense oligonucleotides with anticancer properties and methods of obtaining them, distinct in that in the capacity of oligonucleotides, a mixture of the products of the hydrolysis of polynucleotides is used, and modification is done through changing the molecular charges of the nucleotide bases to their opposites; they thereby obtain antisense properties. The hydrolysis of polynucleotides leads to the application of natural or synthetic nucleases, acid or alkaline hydrolysis, and modification of the structure through the acylation of the amino groups of mononucleotides in the structure of oligonucleotides by dicarboxylic acids or through their alkylation by halogen-carboxylic acids. The mixture developed is capable of selectively bonding with microRNA, thereby stopping the synthesis of protein in cancer cells that is similar to microRNA activity. The application of this drug in connection with its ability to adapt to the body allows the elimination of a tumor's tolerance to the drug. This drug has a wide spectrum of activity and a low level of toxicity; it is accessible for industrial production and effective at any stage of cancer.
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