发明名称 |
Compositions of Orthogonal Lysyl-tRNA and Aminoacyl-tRNA Synthetase Pairs and Uses Thereof |
摘要 |
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are provided in response to a four base codon. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with homoglutamines using these orthogonal pairs. |
申请公布号 |
US2012129215(A1) |
申请公布日期 |
2012.05.24 |
申请号 |
US201113246490 |
申请日期 |
2011.09.27 |
申请人 |
ANDERSON J. CHRISTOPHER;WU NING;SANTORO STEPHEN;SCHULTZ PETER G.;THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
ANDERSON J. CHRISTOPHER;WU NING;SANTORO STEPHEN;SCHULTZ PETER G. |
分类号 |
C12N9/00;C12N;C12P21/00 |
主分类号 |
C12N9/00 |
代理机构 |
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地址 |
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