发明名称 |
PHARMACEUTICAL COMPOSITION FOR PROMOTING ANGIOGENESIS, AND METHOD FOR SCREENING FOR ACTIVE SUBSTANCES FOR PROMOTING ANGIOGENESIS |
摘要 |
The present invention relates to a pharmaceutical composition for promoting angiogenesis, containing an antibody that specifically binds to heat shock protein (HSP) 27. In addition, the present invention relates to a pharmaceutical composition containing an antibody that specifically binds to heat shock protein (HSP) 27, for treating an angiogenesis-dependent ailment selected from a group consisting of a wound, chronic ulcer, ischemic stroke, myocardial infarction, angina pectoris, and cerebrovascular dementia. In addition, the present invention relates to a method for promoting the in vitro growth of endothelial cells using an antibody that specifically binds to HSP27. In addition, the present invention relates to a method for screening for active substances for promoting angiogenesis or for active substances for treating an angiogenesis-dependent ailment, said method comprising the following steps: treating vascular endothelial cell lines with each specimen; measuring the content of HSP27 in the respective vascular endothelial cell lines; and selecting a specimen in which the HSP27 content in the vascular endothelial cell lines are decreased as compared to a control group. |
申请公布号 |
WO2012023810(A3) |
申请公布日期 |
2012.05.24 |
申请号 |
WO2011KR06065 |
申请日期 |
2011.08.18 |
申请人 |
KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES;LEE, YOON JIN;LEE, YUN-SIL;LEE, HAE-JUNE;CHOI, SEO-HYUN;KIM, KYENG-JUNG |
发明人 |
LEE, YOON JIN;LEE, YUN-SIL;LEE, HAE-JUNE;CHOI, SEO-HYUN;KIM, KYENG-JUNG |
分类号 |
A61K39/395;A61P9/00;A61P9/04;A61P9/10 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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