Internalizing Anti-CD74 Antibodies and Methods of Use

摘要

U.W INfLAfMDWU3/_1. / U I UU Abstract This invention relates to an anti-CD74 antibody or antigen-binding fragment thereof, wherein said antibody is known to be internalized by Raji lymphoma cells in culture and said antibody is known to induce apoptosis of Raji cells in cell culture when cross-linked with goat antisera reactive with the Fc of a human IgG.