DIPEPTIDE ANALOGS FOR TREATING CONDITIONS ASSOCIATED WITH AMYLOID FIBRIL FORMATION
摘要
Dipeptide analogs comprising a tryptophan (Trp) moiety coupled to a beta-sheet breaker moiety derived from alpha-aminoisobutyric acid (Aib) are disclosed. The didpeptide analogs exhibit an improved performance in inhibiting amyloid fibril formation, as compared to previously described dipeptides. Compositions containing the didpetide analogs and uses thereof in treating amyloid-associated diseases and disorders are also disclosed.
申请公布号
CA2817830(A1)
申请公布日期
2012.05.24
申请号
CA20112817830
申请日期
2011.11.15
申请人
RAMOT AT TEL AVIV UNIVERSITY LTD.;MERZ PHARMA GMBH & CO. KGAA