发明名称 |
METAL COMPLEXES HAVING DUAL HISTONE DEACETYLASE INHIBITORY AND DNA-BINDING ACTIVITY |
摘要 |
Compounds comprising a metal complex having the structure [X—Y—Z-Mn+]p+.B are disclosed in which X is a histone deacetylase inhibitor, Mn+ is a DNA-binding heavy metal ion, Y is an aliphatic or aromatic spacer or is absent, and Z is a mono- or bi-dentate or chelating donor linker, or a bridging linker, P+ designates the charge on the complex ion, which may be positive, negative or absent and B is a counterion or is absent. The linker Z is labile and its metal complex X—Y—Z-Mn+ is capable of being hydrolysed in-vivo. The compounds find application in the treatment of cancer. |
申请公布号 |
EP2454267(A2) |
申请公布日期 |
2012.05.23 |
申请号 |
EP20100742445 |
申请日期 |
2010.07.13 |
申请人 |
ROYAL COLLEGE OF SURGEONS IN IRELAND |
发明人 |
MARMION, CELINE JOSEPHINE;GRIFFITH, DARREN |
分类号 |
C07F15/00;A61K31/28;C07C259/06;C07C311/21;C07F19/00 |
主分类号 |
C07F15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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