HUMANIZED ANTI-AMYLOID-Î OLIGOMER ANTIBODY.

摘要

A humanized antibody that cannot bind to an Aβ monomer but can bind only to an Aβ oligomer specifically and an antibody drug that comprises the antibody as an active ingredient, can bind specifically to an amyloid-β protein oligomer (an Aβ oligomer) (which is believed to be a causative protein of cognitive impairment or Alzheimer's disease) and therefore can treat Alzheimer's disease have been demanded. Disclosed are: a humanized anti-Aβ oligomer antibody which can bind to an Aβ oligomer specifically; and a method for treating Alzheimer's disease utilizing the humanized antibody. Specifically disclosed are: a therapeutic agent for Alzheimer's disease, a senile plaque formation inhibitor or an Aβ-amyloid fibril formation inhibitor; a method for preventing and/or treating cognitive impairment or Alzheimer's disease, which comprises a step of administering the antibody; and a method for preventing the progression of Alzheimer's disease, which comprises a step of administering the antibody.