| 摘要 |
The invention relates to a radiation treatment apparatus and an inverse treatment planning method for intensity modulated particle therapy for the treatment of a target within a biological system using at least two fields, each field comprising a plurality of Bragg peaks, the at least two fields being planned to place a defined number of beam spots j from different directions with certain weights wj within the target. The inverse treatment planning method optimizes the weights wj of the beam spots for the at least two fields simultaneously in order to produce a prescribed biological effect within the target by minimizing an objective function based on biological effects &egr;, the biological effects &egr; being treated in a linear-quadratic model, which describes the biological effects in the target by two parameters α and &bgr;, where &egr;=αD+&bgr;D2, D denoting a dose, and wherein the two parameters α and &bgr; for each voxel i of the target (αi and &bgr;i) are calculated as dose-averaged mean values of αi,j- and √{square root over (&bgr;i,j)}-components, which relate to all beam spots j contributing to a total dose Di in the voxel i. |
