发明名称 |
Peptide aptamer for neutralizing the binding of platelet antigen specific antibodies and diagnostic and therapeutic applications containing the same |
摘要 |
The present invention relates to a peptide aptamer which mimics particularly the human platelet antigene HPA-Ia epitope present on the platelet GPIIb/IIIa molecules and which is capable of neutralizing the binding of HPA-I a specific antibodies (anti-HPA-1 a). This peptide aptamer is advantageously used in a method for detecting and identifying HPA-I a specific antibodies in human serum, in a diagnostic kit for screening and identifying antibodies, in an immunoassay and a pharmaceutical composition. |
申请公布号 |
US8183055(B2) |
申请公布日期 |
2012.05.22 |
申请号 |
US20070278475 |
申请日期 |
2007.02.07 |
申请人 |
RIGAL DOMINIQUE;THIBAUT JULIEN;GILLET GEMAIN;MERIEUX YVES;STIFTUNG FUER DIAGNOSTISCHE FORSCHUNG |
发明人 |
RIGAL DOMINIQUE;THIBAUT JULIEN;GILLET GEMAIN;MERIEUX YVES |
分类号 |
A61K38/10;C07K7/08;G01N33/564 |
主分类号 |
A61K38/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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