| 摘要 |
FIELD: medicine. ^ SUBSTANCE: engineered recombinant protein molecule for preparing a recombinant vaccine for an infection caused by swine influenza virus (HlNlv-2009). The molecule consists of a residue of methionine, a sequence of extracellular M2 protein domain of 2 to 24 amino acids and a sequence of a nuclear hepatitis B virus antigen of 4 to 149 amino acids. The molecule is able to form virus-like particles. There are also disclosed a recombinant nucleic acid coding such molecule, a vector for its expression, virus-like particles formed by such molecules and a vaccine based on the prepared virus-like particles. ^ EFFECT: prepared vaccine can be considered as a candidate recombinant swine influenza virus vaccine. ^ 6 cl, 8 dwg, 3 tbl, 5 ex |
