| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to novel compounds of formula 1c ^ , where A, B, R1, R2 and n have values given in the description, and pharmaceutically acceptable salts thereof. The invention also relates to pharmaceutical compositions based on compounds of formula 1c, which are used as modulators of ATP-binding cassette ("ABC") transporters or fragments thereof, including cystic fibrosis transmembrane conductance regulator ("CFTR"). The present invention also relates to a method of modulating ABC-transporter activity and methods of treating ABC-transporter mediated diseases using compounds of formula 1c. ^ EFFECT: improved method. ^ 32 cl, 3 tbl, 118 ex |
