发明名称 |
CHEMICAL PREPARATION METHOD OF SKELETAL MUSCLE-DERIVED MULTIPOTENT CELLS AND USE THEREOF |
摘要 |
The present invention provides a chemical preparation method of skeletal muscle-derived multipotent cells comprising: (a) a step for obtaining differentiated cells from mammals; and (b) a step for obtaining multipotent cells by treating the differentiated cells with a dedifferentiation agent after inducing the down-regulation of p21 expression of the differentiated cells. The multipotent cells of the invention enable not only dedifferentiation into a musculogenesis cell population but also the transdifferentiation into an adipogenesis cell population or an osteogenesis cell population. Therefore, the chemical-based approach method of the invention is important in the development of strategies for inducing limb regeneration in mammals. In addition, the invention discloses a new approach method for the development of induced pluripotent stem cells (iPSCs) from completely differentiated refractory tissues. |
申请公布号 |
WO2012064090(A2) |
申请公布日期 |
2012.05.18 |
申请号 |
WO2011KR08473 |
申请日期 |
2011.11.08 |
申请人 |
GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY;WILLIAMS, DARREN, R.;JUNG, DA-WOON |
发明人 |
WILLIAMS, DARREN, R.;JUNG, DA-WOON |
分类号 |
C12N5/077;A61K35/34;A61P21/00;C12N5/02 |
主分类号 |
C12N5/077 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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