MATERIALS AND METHODS FOR DIRECTING AN IMMUNE RESPONSE TO AN EPITOPE
摘要
The present invention relates to compositions, kits, and methods useful for directing an immune response to an epitope of an antigen in a subject, by sensitizing the subject to the epitope and/or by tolerizing the subject to the epitope. The sensitizing method comprises co-administering to the subject the epitope and an immunoglobulin M (IgM) constant region (IgM Fc region). The tolerizing method comprises co-administering to the subject the epitope and an immunoglobulin G (IgG) constant region (IgG Fc region) to the subject.
申请公布号
WO2012064760(A2)
申请公布日期
2012.05.18
申请号
WO2011US59806
申请日期
2011.11.08
申请人
BIOVEST INTERNATIONAL, INC.;SANTOS, CARLOS;POPA-MCKIVER, MIHAELA;MCCORD, AMY M.;HIRSCHEL, MARK
发明人
SANTOS, CARLOS;POPA-MCKIVER, MIHAELA;MCCORD, AMY M.;HIRSCHEL, MARK