N-TERMINAL DELETION VARIANT OF HUMAN FIBROBLAST GROWTH FACTOR 21 AND CONJUGATE THEREOF

摘要

Provided is a variant of human fibroblast growth factor 21 which has a deletion of 9 amino acids at N-terminal of natural wild type human fibroblast growth factor 21. Also provided is a conjugate of the variant, which is obtained by chemical modification of the variant with polyethylene glycol derivatives. Also provided is the use of the variant and conjugate in the manufacture of a medicament for the treatment or prevention of obesity, diabetes, hyperglycemia or hyperlipidemia.