发明名称 |
SUBCUTANEOUSLY ADMINISTERED ANTI-IL-6 RECEPTOR ANTIBODY |
摘要 |
The present application discloses methods for treating an IL-6-mediated disorder such as rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), systemic JIA (sJIA), polyarticular course JIA (pcJIA), systemic sclerosis, or giant cell arteritis (GCA), with subcutaneously administered antibody that binds interleukin-6 receptor (anti-IL-6R antibody). In particular, it relates to identification of a fixed dose of anti-IL-6R antibody, e.g. tocilizumab, which is safe and effective for subcutaneous administration in patients with IL-6-mediated disorders. In addition, formulations and devices useful for subcutaneous administration of an anti-IL-6R antibody are disclosed. |
申请公布号 |
WO2012064627(A2) |
申请公布日期 |
2012.05.18 |
申请号 |
WO2011US59519 |
申请日期 |
2011.11.07 |
申请人 |
GENENTECH, INC.;F. HOFFMANN-LA ROCHE AG;BAO, MIN;HARARI, OLIVIER ALFRED;JAHREIS, ANGELIKA M.;SCHMIDT, JOHANNES F.;ZHANG, XIAOPING |
发明人 |
BAO, MIN;HARARI, OLIVIER ALFRED;JAHREIS, ANGELIKA M.;SCHMIDT, JOHANNES F.;ZHANG, XIAOPING |
分类号 |
C07K16/28;A61K38/47;A61K39/395 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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