COMPOSITIONS AND METHODS FOR GENERATING ADENO-ASSOCIATED VIRAL VECTORS WITH UNDETECTABLE CAPSID GENE CONTAMINATION
摘要
In one aspect, the present invention provides an intron-modified cap expression cassette useful for generating adeno-associated virus (AAV) vector particles. In another aspect, the present invention provides a method of reducing the immune response in a mammalian subject undergoing treatment with an AAV vector.
申请公布号
WO2012064960(A2)
申请公布日期
2012.05.18
申请号
WO2011US60193
申请日期
2011.11.10
申请人
FRED HUTCHINSON CANCER RESEARCH CENTER;MILLER, ARTHUR, DUSTY;HALBERT, CHRISTINE, L.;METZGER, MICHAEL, J.
发明人
MILLER, ARTHUR, DUSTY;HALBERT, CHRISTINE, L.;METZGER, MICHAEL, J.