发明名称 |
GAS-FILLED MICROBUBBLES AND SYSTEMS FOR GAS DELIVERY |
摘要 |
Compressible and concentrated suspensions containing gas-filled microbubbles, uses thereof for delivering gas into a subject in need thereof, and systems for delivering the compressible suspensions. The gas-filled microbubbles each comprise a gas core surrounded by a lipid membrane, which includes (a) one or more lipids, such as 1,2-disteroyl-sn-glycero- 3-phosphocholine (DSPC) or dipalmitoylphosphatidylcholine (DPPC), and (b) one or more stabilizing detergents, such as poloxamer 188, Pluronic F108, Pluronic F127, polyoxyethylene (100) stearyl ether, cholesterol, gelatin, polyvinylpyrrolidone (PVP), and sodium deoxycholate (NaDoc). |
申请公布号 |
WO2012065060(A2) |
申请公布日期 |
2012.05.18 |
申请号 |
WO2011US60368 |
申请日期 |
2011.11.11 |
申请人 |
CHILDREN'S MEDICAL CENTER CORPORATION;KHEIR, JOHN;MCGOWAN, FRANCIS, X.;LOXLEY, ANDREW;LEE, ROBERT |
发明人 |
KHEIR, JOHN;MCGOWAN, FRANCIS, X.;LOXLEY, ANDREW;LEE, ROBERT |
分类号 |
A61K47/48;A61K9/127;A61K9/24;A61K9/46;A61K47/30 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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