发明名称 |
COMPOSITIONS AND METHODS USING ALPHA BETA-CRYSTALLIN IN PROTECTING THE MYOCARDIUM FROM ISCHEMIA/REPERFUSION INJURY |
摘要 |
The invention provides a modified version of alpha B-Crystallin (αBC), and methods for delivering this modified version of alpha B-Crystallin (αBC) to tissues and cells; the invention provides a modified version of αBC in which the serine at position 59 has been changed to glutamate to mimic phosphorylation and the serine at positions 19 and 45 have been changed to alanine to prevent phosphorylation of those residues. The invention also provides compositions and methods for ameliorating a cell from ischemia/reperfusion injury or protecting a cell from ischemia/reperfusion injury. |
申请公布号 |
US2012124684(A1) |
申请公布日期 |
2012.05.17 |
申请号 |
US200913132249 |
申请日期 |
2009.12.01 |
申请人 |
GLEMBOTSKI CHRISTOPHER C.;WHITTAKER ROSS J.;SAN DIEGO STATE UNIVERSITY (SDSU) FOUNDATION |
发明人 |
GLEMBOTSKI CHRISTOPHER C.;WHITTAKER ROSS J. |
分类号 |
A01K67/027;A61K38/16;C07H21/04;C07K14/00;C12N5/00;C12N5/02;C12N5/10;C12N15/63 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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