METHOD AND COMPOSITION FOR DIAGNOSING ANKYLOSING SPONDYLITIS BY USING BIOMARKER

摘要

PROBLEM TO BE SOLVED: To provide a method for determining effectiveness of a TNF α inhibitor such as a TNF α antibody or its antigen binding part for medical treatment of ankylosing spondylitis (AS).

SOLUTION: A method for determining effectiveness of a TNF α inhibitor includes steps of: comparing predetermined levels of a collagen degradation biomarker and/or a synovitis biomarker obtained from an ankylosing spondylitis (AS) patient after medical treatment using a human TNF α antibody with known standard levels of a collagen degradation biomarker and/or a synovitis biomarker relevant to a clinical condition; and evaluating whether or not levels of the collagen degradation biomarker and/or the synovitis biomarker after the medical treatment of the patient are lower than the known standard levels of the collagen degradation biomarker and/or the synovitis biomarker, and effectiveness of the human TNF α antibody for the medical treatment of AS is indicated by a fact that the levels of the collagen degradation biomarker and/or the synovitis biomarker obtained from the patient after the medical treatment using the human TNF α antibody are lower than the known standard levels.

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