发明名称 LACTAM COMPOUND USEFUL AS PROTEIN KINASE INHIBITOR
摘要 <P>PROBLEM TO BE SOLVED: To provide inhibitors of protein kinase. <P>SOLUTION: There are provided new compounds useful as inhibitors of protein kinase represented by formula (I) and pharmaceutically acceptable salts thereof, wherein A, R<SP POS="POST">a</SP>, R<SP POS="POST">b</SP>, R<SP POS="POST">c</SP>, R<SP POS="POST">d</SP>, G<SP POS="POST">1</SP>, Y<SP POS="POST">1</SP>and Y<SP POS="POST">2</SP>have meanings described in the scope of claims. The pharmaceutical compositions comprising the compounds and methods of using the compositions in the treatment of various diseases are also provided. The compounds are useful for inhibiting kinase activity in vitro or in vivo, and are especially useful for the treatment of various proliferative diseases. <P>COPYRIGHT: (C)2012,JPO&INPIT
申请公布号 JP2012092143(A) 申请公布日期 2012.05.17
申请号 JP20120019746 申请日期 2012.02.01
申请人 MILLENNIUM PHARMACEUTICALS INC 发明人 BLACKBURN CHRISTOPHER;CLAIBORNE CHRISTOPHER F;CULLIS COURTNEY A;DALES NATALIE A;PATANE MICHAEL A;STIRLING MATTHEW;STRADELLA OMAR G;WEATHERHEAD GABRIEL S
分类号 C07D471/14;A61K31/55;A61K45/00;A61P35/00;C07D487/04;C12N9/99 主分类号 C07D471/14
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