发明名称 |
Bicyclic pyridines and analogs as sirtuin modulators |
摘要 |
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. |
申请公布号 |
AU2010319842(A1) |
申请公布日期 |
2012.05.17 |
申请号 |
AU20100319842 |
申请日期 |
2010.10.29 |
申请人 |
SIRTRIS PHARMACEUTICALS, INC. |
发明人 |
NG, PUI YEE;BLUM, CHARLES;MCPHERSON, LAUREN;PERNI, ROBERT B.;VU, CHI B.;AHMED, MOHAMMED MAHMOOD;DISCH, JEREMY S. |
分类号 |
C07D471/04;A61K31/437;A61K31/4375;A61K31/4985;A61K31/5365;A61K31/55;A61K31/551;A61K31/553;A61P5/50;C07D487/04;C07D519/00 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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