发明名称 |
NEW MEDICINES FOR TOPIC USE BASED ON SULFATED HYALURONIC ACID AS ACTIVATING OR INHIBITING AGENT OF THE CYTOKINE ACTIVITY |
摘要 |
The object of the present invention relates to the new and surprising use of sulfated hyaluronic acid (HAS) as regulator agent of the cytokine activity (pro- and anti-inflammatory) and consequently the use of HAS for the preparation of a new medicine for topic use in the prevention and treatment of pathologies associated with the activation and/or deficiency of cytokines of a pro- and anti-inflammatory nature. The Applicant has in fact discovered the exclusive capacity of HAS in modulating the activity of these particular proteins, it has studied the action mechanism and demonstrated the substantial difference between the different sulfated types known in the state of the art, but above all it has demonstrated an unexpectedly high activity of HAS vs different types and strains of Herpes virus, Cytomegalovirus and the virus of vesicular stomatitis. Finally, a further object of the present invention is the use of HAS as a skin absorption promoter of drugs of an anti-inflammatory nature.
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申请公布号 |
US2012121572(A1) |
申请公布日期 |
2012.05.17 |
申请号 |
US201013320000 |
申请日期 |
2010.05.14 |
申请人 |
D'ESTE MATTEO;GENNARI GIOVANNI;FIDIA FARMACEUTICI S.P.A. |
发明人 |
D'ESTE MATTEO;GENNARI GIOVANNI |
分类号 |
A61K31/737;A61K38/02;A61K38/43;A61K38/47;A61K38/48;A61P7/02;A61P11/06;A61P17/00;A61P17/06;A61P29/00;A61P31/22;A61P35/00;A61P37/06;C08B37/08 |
主分类号 |
A61K31/737 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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