| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a series of compounds which modulate the function of the nuclear hormone receptors, especially the androgen receptor. <P>SOLUTION: The invention relates to compounds of hydantoin, methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example, prostate cancer, and to pharmaceutical compositions containing such compounds. In an embodiment, a pharmaceutical composition includes a therapeutically effective amount of a compound according to formula II, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent, or adjuvant. A series of compounds which modulate the function of the nuclear hormone receptors, especially the androgen receptor are provided. The compounds can cause disappearance of prostate cancer cells and tumors. <P>COPYRIGHT: (C)2012,JPO&INPIT |
