发明名称 |
MONOCLONAL ANTIBODIES AND THEIR USE |
摘要 |
Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic endocrine cells or a subset thereof, and/or a precursor thereof. Isolated monoclonal antibodies are also disclosed herein that specifically bind a cell surface antigen expressed on human pancreatic exocrine cells or human ductal cells. Humanized forms of these antibodies, and functional fragments of these antibodies, are also disclosed. The antibodies can be conjugated to an effector molecule, or a detectable marker. These antibodies are of use to detect and/or isolate pancreatic cells or a subset thereof. Methods of treating a pancreatic tumor are also disclosed. |
申请公布号 |
US2012121512(A1) |
申请公布日期 |
2012.05.17 |
申请号 |
US201113324929 |
申请日期 |
2011.12.13 |
申请人 |
GROMPE MARKUS;STREETER PHILIP R.;DORRELL CRAIG;ABRAHAM STEPHANIE L.;SHOOP KELSEA M.;OREGON HEALTH & SCIENCE UNIVERSITY |
发明人 |
GROMPE MARKUS;STREETER PHILIP R.;DORRELL CRAIG;ABRAHAM STEPHANIE L.;SHOOP KELSEA M. |
分类号 |
C07K16/28;A61K39/395;A61K49/00;A61P35/00;C07H21/04;C07K17/00;C07K19/00;C12N1/19;C12N1/21;C12N5/00;C12N5/071;C12N5/10;C12N5/16;C12N15/63;G01N33/567 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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