发明名称 |
LYOPHILIZED PREPARATION COMPRISING INFLUENZA VACCINE, AND METHOD FOR PREPARATION THEREOF |
摘要 |
<p>The present invention aims to provide a freeze-dried preparation in which the influenza vaccine exhibits improved stability. A freeze-dried preparation in which the influenza vaccine exhibits significantly improved stability can be obtained by freeze-drying an aqueous solution that meets the following conditions (A) to (C):
(A) (i) an influenza vaccine, (ii) a hydrophobic amino acid, and (iii) arginine and an acid addition salt thereof are incorporated;
(B) the proportion of the component (iii) is from 20 to 85% by weight relative to the total amount of the resulting freeze-dried preparation; and
(c) the pH is adjusted to be from 8 to 10 by controlling the proportion of arginine and an acid addition salt thereof that form the component (iii).</p> |
申请公布号 |
EP2119451(A4) |
申请公布日期 |
2012.05.16 |
申请号 |
EP20080721627 |
申请日期 |
2008.03.07 |
申请人 |
OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
YAMASHITA, CHIKAMASA |
分类号 |
A61K39/145;A61K9/19;A61K47/18;A61P31/16 |
主分类号 |
A61K39/145 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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