FORMULATIONS OF 6- (5-CHLORO-2-PYRIDYL) - 5- [ (4-METHYL-1-PIPERAZINYL) CARBONYLOXY]- 7-0X0-6, 7- DIHYDRO- 5H- PHYRROLO [3, 4-B]PYRAZINE

摘要

Pharmaceutical compositions of zopiclone [(6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine)] that render the aqueous solubility/dissolution of the free base independent of the pH of the gastrointestinal tract are disclosed. The compositions are useful for oral administration.