发明名称 |
DIPHENYL SULFIDE DERIVATIVES AND MEDICINES CONTAINING THEM AS ACTIVE INGREDIENT |
摘要 |
Provided are diphenyl sulfide derivatives which have excellent S1P3 antagonistic activity and are useful as drugs. Intensive studies have been made for the purpose of creating a compound having S1P3 antagonistic activity. As a result of the intensive studies, it has been found that diphenyl sulfide derivatives representedby general formula (1) have excellent S1P3 antagonistic activity. In general formula (1), R 1 is a hydrogen atom or the like; R 2 is an optionally substituted alkyl group having 1 to 6 carbon atoms, or the like; X is a methylene group which may be substituted with one or two fluorine atoms, or the like; Y is a hydrogen atom or the like; and Z is a halogen atom. |
申请公布号 |
EP2452944(A1) |
申请公布日期 |
2012.05.16 |
申请号 |
EP20100796915 |
申请日期 |
2010.07.08 |
申请人 |
KYORIN PHARMACEUTICAL CO., LTD. |
发明人 |
KOHNO, YASUSHI;FUJII, KIYOSHI;TARU, MOMOKO;MIYOSHI, KEITA |
分类号 |
C07F9/09;A61K31/662;A61P31/04;A61P43/00;C07F9/38 |
主分类号 |
C07F9/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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