PHARMACEUTICAL COMPOSITION FOR THE PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE CONTAINING URSODEOXYCHOLIC ACID GINKGO BILOBA EXTRACT

摘要

PURPOSE: A composition containing ursodeoxycholic acid and ginkgo extract is provided to rise recognition memory and cholinergic nervous system function and to suppress amyloid plaque formation. CONSTITUTION: A pharmaceutical composition for preventing and treating Alzheimer's diseases contains ursodeoxycholic acid and ginkgo leaf extract as an active ingredient. The effect of the pharmaceutical composition is tested by Y maze test, novel object test, and passive avoidance test. The amyloid is detected at cortex and hippocampus of APPswe/PS1De9 dual-expressed mouse by immunohistochemistry.