发明名称 Tetra-substituted NDGA derivatives via ether bonds and carbamate bonds and their synthesis and pharmaceutical use
摘要 Disclosed are nordihydroguaiaretic acid derivative compounds including various end groups bonded by a carbon atom or heteroatom though a side chain bonded to the respective hydroxy residue O groups by an ether bond or a carbamate bond, pharmaceutical compositions, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, a metabolic disease, such as diabetes, a vascular disease, such as hypertension and macular degeneration, or a proliferative disease, such as diverse types of cancers.
申请公布号 US8178527(B2) 申请公布日期 2012.05.15
申请号 US20070443906 申请日期 2007.10.02
申请人 CHEN QINGQI;LOPEZ ROCIO ALEJANDRA;HELLER JONATHAN DANIEL;MORRIS AMANDA JEAN;ERIMOS PHARMACEUTICALS LLC 发明人 CHEN QINGQI;LOPEZ ROCIO ALEJANDRA;HELLER JONATHAN DANIEL;MORRIS AMANDA JEAN
分类号 A61K31/495;A61K31/085;A61K31/132;A61K31/165;A61K31/341;A61K31/426;A61K31/445;A61K31/5375;C07C271/02;C07C271/46;C07D211/06;C07D241/04;C07D277/24;C07D307/52;C07D413/14 主分类号 A61K31/495
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