| 发明名称 |
COMBINATIONS COMPRISING EPOTHILONE DERIVATIVES AND ALKYLATING AGENTS |
| 摘要 |
The invention relates to a pharmaceutical combination which comprises (a) an alkylating agent and (b) an epothilone derivative of formula (I) wherein A represents O or NRN, wherein RN is hydrogen or lower alkyl, R is hydrogen or lower alkyl, and Z is O or a bond. Said combination can be useful for the treatment of a proliferative disease, especially a tumor disease.
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| 申请公布号 |
CA2478223(C) |
申请公布日期 |
2012.05.15 |
| 申请号 |
CA20032478223 |
申请日期 |
2003.03.07 |
| 申请人 |
NOVARTIS AG;UNIVERSITY OF NEWCASTLE UPON TYNE |
发明人 |
ANDERSON, JUDITH ROSE;ROTHERMEL, JOHN DAVID;MC SHEEHY, PAUL M.J.;BODDY, ALAN |
| 分类号 |
A61K31/425;A61K45/00;A61K31/427;A61K31/565;A61K45/06;A61P35/00;A61P35/02;A61P35/04;A61P43/00 |
主分类号 |
A61K31/425 |
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