THERMAL REACTION DEVICE AND METHOD FOR USING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide devices that can be utilized to conduct a variety of nucleic acid amplification reactions, while having sufficient versatility for use in other types of analyses as well.

SOLUTION: An M×N matrix microfluidic device for performing a matrix of reactions is disclosed. This device (100) has a plurality of reaction cells (106) in communication with one of either a sample inlet (120) or a reagent inlet (124) through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of the microfluidic device. The method includes a step of using patterned photoresist masks and a step of etching regions or portions of an elastomeric layer of the elastomeric block.

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