发明名称 |
BISMUTH-CONTAINING COMPOUNDS, COORDINATION POLYMERS, METHODS FOR MODULATING PHARMACOKINETIC PROPERTIES OF BIOLOGICALLY ACTIVE AGENTS, AND METHODS FOR TREATING PATIENTS |
摘要 |
Bismuth-containing compounds include bismuth and a biologically active agent coordinated to the bismuth. The biologically active agent includes at least one heteroatom configured for coordination with the bismuth. Coordination polymers include a polymer matrix that contains a bismuth-containing compound. Methods for modulating a pharmacokinetic property of a biologically active agent include coordinating the biologically active agent to bismuth to form a bismuth-containing compound, and administering the bismuth-containing compound orally to a patient. Methods for treating Parkinson's disease, methods for treating hypothyroidism, methods for treating ulcerative colitis, and methods for treating cancer each include administering a bismuth-containing compound to a patient. |
申请公布号 |
US2012115823(A1) |
申请公布日期 |
2012.05.10 |
申请号 |
US20100941599 |
申请日期 |
2010.11.08 |
申请人 |
PRICE JOHN D.;PICCARIELLO THOMAS;OBERLENDER ROBERT A.;MULHARE MICHAELA E.;PALMER SCOTT B. |
发明人 |
PRICE JOHN D.;PICCARIELLO THOMAS;OBERLENDER ROBERT A.;MULHARE MICHAELA E.;PALMER SCOTT B. |
分类号 |
A61K31/29;A61K31/606;A61P1/00;A61P5/14;A61P25/16;A61P29/00;A61P35/00;C07F9/94;C07H23/00;C07K2/00;C08B11/08;C08B37/00;C08B37/04;C08B37/06;C08B37/08 |
主分类号 |
A61K31/29 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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