| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a vaccine that can prevent human cytomegalovirus (HCMV) in latent infection from being activated and producing a disease. <P>SOLUTION: This invention relates to: the vaccine against the HCMV, comprising a plurality of peptides (and immunologically functional variants thereof) which are immunogenic epitopes recognized by CD8<SP POS="POST">+</SP>class I MHC restricted cytotoxic T-lymphocytes of patients harboring latent HCMV infection; or a lipidated peptide, a DNA adjuvant, or a cellular vaccine having antigen presenting cells; and virus vector vaccine for coding the peptide. These vaccines are capable of activating CTLs and CTLps against the HCMV, and thus are useful for eliciting a cellular immune response against HCMV. <P>COPYRIGHT: (C)2012,JPO&INPIT |
