TF-BPB SPECIFICALLY BINDING TO TRANSCRIPTION FACTOR

摘要

The present invention relates to a TF-bipodal peptide binder specifically binding to TF, comprising: (a) a structure stabilizing region comprising parallel, antiparallel, or parallel and antiparallel amino acid strands in which an interstrand noncovalent bond is formed; and (b) a TF-target binding region I and a TF-target binding region II which bind respectively to both ends of the structure stabilizing region and comprise randomly selected n and m amino acids, respectively. The TF-bipodal peptide binder of the present invention shows a very low level (for example, nM level) of KD value (dissociation constant) to TF, thereby showing very high affinity to a TF target. The TF-bipodal peptide binder of the present invention has a medical use, can be used for in vivo molecular imaging and targeting for drug delivery, and also can be very usefully used as an escort molecule.