METHOD OF FORMING SELF-SUPPORTING FILM FOR DELIVERY OF THERAPEUTIC AGENT

摘要

PROBLEM TO BE SOLVED: To provide self-supporting films for delivery of a therapeutic agent which does not require the support of a medical device and which displays enhanced therapeutic payload.

SOLUTION: A method of forming the films for delivery of the therapeutic agent includes steps of: providing a substrate; providing a first solution which contains at least one hydrophobic polymer; providing a second solution which contains at least one water-soluble therapeutic agent; passing the first solution through a first spray nozzle to generate first droplets of the first solution; depositing the first droplets on the substrate to form a first layer; passing the second solution through a second spray nozzle to generate second droplets of the second solution; depositing the second droplets on the first layer to form a second layer; and drying the first and second layers to form a multilayered film.

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