发明名称 |
METHODS OF TREATMENT USING LIPID COMPOUNDS |
摘要 |
Methods are disclosed to treat or prevent at least one disease or condition in a subject in need thereof comprising administering a compound of Formula (I): (I) or a pharmaceutically acceptable salt, or ester thereof, wherein R1 and R2 are independently chosen from a hydrogen atom or linear, branched, and/or cyclic C1-C6 alkyl groups, with the proviso that R1 and R2 are not both hydrogen or a pharmaceutically acceptable salt or ester thereof. Such diseases or conditions may relate to coronary heart disease (CHD), for example atherosclerosis; metabolic syndrome/insulin resistance; and/or a dyslipidemic condition such as hypertriglyceridemia (HTG), elevated LDL- cholesterol, elevated total-cholesterol, elevated Apo B and low HDL-cholesterol. The present disclosure further provides for a method of reducing atherosclerosis development. Pharmaceutical compositions comprising a compound of Formula (I) are also disclosed. |
申请公布号 |
WO2012059818(A1) |
申请公布日期 |
2012.05.10 |
申请号 |
WO2011IB02925 |
申请日期 |
2011.11.03 |
申请人 |
PRONOVA BIOPHARMA NORGE AS;HOVLAND, RAGNAR;SKJAERET, TORE;FRASER, DAVID A. |
发明人 |
HOVLAND, RAGNAR;SKJAERET, TORE;FRASER, DAVID A. |
分类号 |
A61K31/19;A61P3/04;A61P3/06;A61P3/10;A61P9/10;C07C57/03 |
主分类号 |
A61K31/19 |
代理机构 |
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代理人 |
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地址 |
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