发明名称 |
HOMOZYGOUS AND HETEROZYGOUS IDH1 GENE-DEFECTIVE CELL LINES DERIVED FROM HUMAN COLORECTAL CELLS |
摘要 |
IDH1 gene-defective cell lines (e.g., IDH1R132H heterozygous) have been made from a robust cell line, HCT116. The IDH1 gene-defective cell lines can be used to determine the effect of IDH1R132H on cell biology, tumorigenesis, and cellular metabolic profiles. These cell lines can be used to test potential therapeutic targets and to screen potential therapeutic agents. Kits and xenografts are also contemplated. |
申请公布号 |
WO2012061105(A2) |
申请公布日期 |
2012.05.10 |
申请号 |
WO2011US57615 |
申请日期 |
2011.10.25 |
申请人 |
DUKE UNIVERSITY;YAN, HAI;BIGNER, DARRELL;DUNCAN, CHRIS |
发明人 |
YAN, HAI;BIGNER, DARRELL;DUNCAN, CHRIS |
分类号 |
C12N5/10;A01K67/027;C12N5/09;C12N15/85 |
主分类号 |
C12N5/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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