There is provided a method of identifying a protective Leptospiravaccine composition, comprising determining that the composition contains a protective concentration of a Lipl32 epitope polypeptide, for example, of a polypeptide comprising SEQ ID NO:13or an antigenic variant or portion thereof. There is also provided a vaccine composition comprising a protective concentration of at least one Lipl32 epitope polypeptidehaving up to 250 amino acids and comprising SEQ ID NO:13or an antigenic variant or portion thereof. There is further provided a method of identifying an immunogenic element in a vaccine composition comprising submitting the composition to a two-dimensional liquid chromatography mass spectrometry (2D LC/MS) process.
申请公布号
WO2012035330(A3)
申请公布日期
2012.05.10
申请号
WO2011GB51711
申请日期
2011.09.13
申请人
THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD & RURAL AFFAIRS;HUMPHRYES, PHILLIP C;COLDHAM, NICHOLAS G