BLUE-COLORED GOLD NANOPARTICLES FOR IMMUNOLOGICAL MEASUREMENT, PROCESS FOR PRODUCTION OF SAME, AND MEASUREMENT METHOD USING SAME

摘要

A nuclei formation step of reacting an organic buffering agent having a piperazine ring with a solution of a first gold salt to form nuclear gold nanoparticles and a growth step of growing the nuclear gold nanoparticles by simultaneously adding a solution of a second gold salt and an organic acid having reducing properties to the solution of the nuclear gold nanoparticles to cause the reaction of these components are carried out. Thus, it becomes possible to readily produce gold nanoparticles which can be dispersed into a colloid solution having a blue color as determined by visual examination and each of which comprises an organic buffering agent having a piperazine ring, gold and an organic acid having reducing properties. The gold nanoparticles thus produced can be used as labeling particles for use in immunological measurement methods.