发明名称 |
SPARC-DERIVED TUMOR REJECTION ANTIGENIC PEPTIDES AND MEDICAMENTS COMPRISING THE SAME |
摘要 |
It is an objective of the present invention to identify SPARC protein-derived peptides that are able to induce human killer T cells and helper T cells having cytotoxic activity to tumors, and to provide a means for carrying out a tumor immunotherapy of patients with various types of cancers overexpressing SPARC. The present invention provides a peptide of any of the following: (A) a peptide which consists of the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3; or (B) a peptide which consists of an amino acid sequence comprising a substitution or addition of one or several amino acids with respect to the peptide consisting of the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3, and which has capacity to induce cytotoxic (killer) T cells.
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申请公布号 |
US2012115221(A1) |
申请公布日期 |
2012.05.10 |
申请号 |
US201113243259 |
申请日期 |
2011.09.23 |
申请人 |
NISHIMURA YASUHARU;IKUTA YOSHIAKI;NAKATSURU SHUICHI;ONCO THERAPY SCIENCE, INC. |
发明人 |
NISHIMURA YASUHARU;IKUTA YOSHIAKI;NAKATSURU SHUICHI |
分类号 |
C12N5/078;C07K7/06;C07K16/18;C12N5/0783;C12N5/10 |
主分类号 |
C12N5/078 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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