<p>The present invention provides an isolated protein comprising an immunoglobulin variable region comprising at least two cysteine residues positioned within framework region 1 such that if at least two of the cysteine residues are not conjugated to another compound a disulphide bond forms between the cysteine residues. Preferably the protein comprises an immunoglobulin heavy chain variable region and an immunoglobulin light chain variable region, wherein at least one of the variable regions comprises the two cysteine residues. The present invention also provides a protein that binds to TAG72. The present invention also provides conjugates of the protein and another compound.</p>
申请公布号
EP2448966(A1)
申请公布日期
2012.05.09
申请号
EP20100793442
申请日期
2010.07.02
申请人
AVIPEP PTY LTD
发明人
HUDSON, PETER, JOHN;SANDERS, PAUL, ROBERT;TAMVAKIS, DEBRA;TURATTI, FABIO;WHEATCROFT, MICHAEL, PAUL;LEONG, DAVID