发明名称 |
SYNTHESIS AND USE OF FLUOROPHORE-TAGGED ANTIMALARIALS |
摘要 |
This invention includes a fluorophore-tagged antimalarial represented by the following structural formula (1) or a salt thereof. This invention relates to the synthesis of fluorophore-tagged antimalarials and describes the synthesis of a fluorophore-tagged antimalarial. These fluorophore-tagged antimalarials can be used to image live cells to determine the location of the antimalarial in the cell, identify drug resistance and growth related pathways in Plasmodium isolates, identify new drug targets and chemo-sensitizers to reverse drug resistance. |
申请公布号 |
EP2448574(A1) |
申请公布日期 |
2012.05.09 |
申请号 |
EP20100794467 |
申请日期 |
2010.06.28 |
申请人 |
NATIONAL UNIVERSITY OF SINGAPORE |
发明人 |
LEAR, MARTIN JAMES;TAN, KEVIN SHYONG WEI |
分类号 |
A61K31/37;A61K31/4706;A61K49/00;A61P33/06;C07D405/12;C07F5/02 |
主分类号 |
A61K31/37 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|