发明名称 |
Controlled-release immunogenic formulations to modulate immune response |
摘要 |
Single-dose controlled-release immunogenic formulations, such as vaccines, based on bioerodible polyanhydride copolymer or homopolymer microparticles for the control of immune response mechanisms are provided. The copolymer or homopolymer microparticles degrade by surface-erosion from in vivo hydrolysis of anhydride linkages at the surface of the microparticle, which results in controlled release of immunogen(s) to a patient. |
申请公布号 |
US8173104(B2) |
申请公布日期 |
2012.05.08 |
申请号 |
US20090554282 |
申请日期 |
2009.09.04 |
申请人 |
KIPPER MATTHEW J.;NARASIMHAN BALAJI;WILSON JENNIFER H.;WANNEMUEHLER MICHAEL J.;IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. |
发明人 |
KIPPER MATTHEW J.;NARASIMHAN BALAJI;WILSON JENNIFER H.;WANNEMUEHLER MICHAEL J. |
分类号 |
A61K49/00;A61K39/00;A61K39/02 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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地址 |
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