发明名称 |
Method for applying NMR for ligand discovery or as a drug screening tool |
摘要 |
The present invention relates to a method for screening compounds to identify compounds that bind to a specific target, comprising the steps of: (a) providing a target immobilized to a solid support; (b) generating a first NMR spectrum of the said compounds to be screened in the presence of the solid support without the target molecule immobilized thereto; (c) generating a second NMR spectrum of the said compounds to be screened in the presence of the solid support with the target molecule immobilized thereto; and (d) comparing said first and second NMR spectrum to determine differences between said first and second NMR spectrum. Further the invention relates to an NMR apparatus having arranged therein a particular NMR probe.
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申请公布号 |
US8173441(B2) |
申请公布日期 |
2012.05.08 |
申请号 |
US20020111251 |
申请日期 |
2002.08.26 |
申请人 |
SIEGAL GREGG DAVID;UNIVERSITEIT LEIDEN |
发明人 |
SIEGAL GREGG DAVID |
分类号 |
G01N24/00;G01N24/08;G01R33/30;G01R33/46;G01R33/465 |
主分类号 |
G01N24/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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