发明名称 |
Multi-nucleated cell classification and micronuclei scoring |
摘要 |
Methods and systems for counting nuclei for cells in a cell-containing sample are disclosed, such as carried out on a computer. The methods comprise: receiving a raw image of the cell-containing sample; transforming the raw image into a segmented image comprising one or more nuclei clusters. The methods further comprise: for each of the one or more nuclei clusters, obtaining a convex hull of the nuclei cluster; locating any indentations on the nuclei cluster by comparing the nuclei cluster to the convex hull of the nuclei cluster; calculating a first nuclei count based on a tally of the indentations; and assigning the nuclei cluster to a cell among the plurality of cells. The methods further comprise: calculating a second nuclei count for each cell by totaling the first nuclei counts of its constituent nuclei clusters; and presenting a result based on the second nuclei count for at least one of the plurality of cells. |
申请公布号 |
US8175369(B2) |
申请公布日期 |
2012.05.08 |
申请号 |
US20080316497 |
申请日期 |
2008.12.12 |
申请人 |
HONG DIHUI;COHEN AVRUM I.;MOLECULAR DEVICES, LLC |
发明人 |
HONG DIHUI;COHEN AVRUM I. |
分类号 |
G06K9/00 |
主分类号 |
G06K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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