发明名称 |
Proteinkompleksdannelse under anvendelse af immunoglobulinfragment samt fremgangsmåde til fremstilling deraf |
摘要 |
Disclosed is a novel use of an immunoglobulin Fc fragment, and more particularly, a pharmaceutical composition comprising an immunoglobulin Fc fragment as a carrier. The pharmaceutical composition comprising an immunoglobulin Fc fragment as a carrier remarkably extends the serum half-life of a drug while maintaining the in vivo activity of the drug at relatively high levels. Also, when the drug is a polypeptide drug, the pharmaceutical composition has less risk of inducing immune responses compared to a fusion protein of the immunoglobulin Fc fragment and a target protein, and is thus useful for developing long-acting formulations of various polypeptide drugs. |
申请公布号 |
DK1682583(T3) |
申请公布日期 |
2012.05.07 |
申请号 |
DK20040800091T |
申请日期 |
2004.11.13 |
申请人 |
HANMI HOLDINGS CO., LTD |
发明人 |
KIM, YOUNG MIN;KIM, DAE JIN;BAE, SUNG MIN;LIM, CHANG KI;KWON, SE CHANG;LEE, GWAN SUN |
分类号 |
A61K47/42;C07K19/00;A61K47/48;C07K16/00;C07K16/42;C12N15/70 |
主分类号 |
A61K47/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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